An amusing anecdote:
The other day I grabbed a volume of Lone Wolf & Cub off the shelf, went to the bookmark I had placed in to save my place several weeks ago, and started reading.
As I read, I had two thoughts: 1) It wasn't making much sense; and 2) it all seemed vaguely familiar.
I was over twenty page into the story before I realized that I was reading it backwards! Recall that Dark Horse published Lone Wolf & Cub in flipped (left-to-right) format, instead of the typical right-to-left format that's used for most translated manga these days!
It made much more sense when I started reading it in the correct direction.
(Well, it was amusing to me...)