The Pick of the Week is the first volume of Mike Grell's The Complete Jon Sable, Freelance from IDW, a classic series getting a deluxe trade collection.
In other comics:
Beckett have a new issue of Fade from Grace (#5), a nice little superhero/romance comic that you all should be reading.
Dark Horse have the final issue of the latest Jingle Belle mini (#4) and the penultimate issue of Concrete: Human Dilema (#5).
DC have the debut of the Englehart/Rogers/Austin mini Batman: Dark Detective; the final issue of Fallen Angel (#20) (though rumors have it returning in the near future from IDW...); the debut of Gail Simone's Infinite Crisis tie-in
Del Rey debut two new manga, Genshiken & Nodame Cantiabile (though I saw both last week at Barnes & Noble...)
Fantagraphics' third volume of The Complete Peanuts hits comic stores (though mine arrived from Amazon last week...)
Image debut a Rising Stars mini, Voices of the Dead (I'm waiting for the trade...) and have a colected edition of The Luna Bros.'s Ultra: Seven Days.
Marvel have the second issues of GLA and Power Pack.
Lots of manga from Viz this week, including volume 30(!) of Ranma 1/2.
Hope you find something you like!