The Pick of the Week is the finale of DC's Infinite Crisis. Worlds will live, worlds will die, etc. etc. Sure to both delight and enrage fanboys in equal quantities (and sometimes within the same person!)
In other comics:
Amaze Ink have the fourth issue of super-cool librarian Rex Libris.
Antarctic have the fourth issue of Rod Espinosa's Alice in Wonderland adaptation, plus the 75th issue of Fred Perry's Gold Digger.
Archaia Studios have the second issue of Mouse Guard.
Boom! Studios have the second issue of War of the Worlds: Second Wave.
Dark Horse have the second issue of BPRD: Universal Machine; a collection of Concrete: The Human Dilema; and the 3rd volume of one of my favorite current manga series, Eden.
DC have collections of Gotham Central (vol. 3) and Sandman Mystery Theatre (vol. 4), two great books that you should have been reading, but now have a second chance. There are also new issues of Action Comics (#838), Detective Comics (#819), JSA (#85), Justice League Unlimited (#21), Swamp Thing (#27), and Y, the Last Man (#45).
Digital Manga have the second Robot anthology.
Fantagraphics have a new issue of Love & Rockets (vol. 2 #16).
Image have their debut of the former Speakeasy title Rocketo (#7). Which is cool if you read the trade and are up to speed; however, if you were trying to read it in floppies you're screwed, because issues #5-6 were never published...
Marvel kick off
TokyoPop have the 13th Kindaichi Case Files: House of Wax.
Viper have a new issue of The Middleman (#2.3).
Which brings us to the end of another week in comics. Enjoy!